Improve your product's performance with accurate characterisationYou want to ensure consistent quality and performance of your formulated product. We offer you advanced characterisation combined with interpretation of the result to help you understand all aspects of your formulation.
We want to make sure your product reaches its full potential and functionality. Often standard characterisation protocols are not enough to pinpoint the exact cause of formulation problems or effects of different processing, excipients, storage treatments etc.
With our combination of advanced instruments, we offer you a complete and accurate characterisation. We then interpret the result, and based on that we also provide expertise advice and support in your further development and production.
Characterisation of tablets
"The coated tablets lack in strength, and the release is to fast. Why?"
A number of analytical tools can be used to pinpoint these issues.
Dissolution / release
This can be related to incomplete coating. The release rate can be measured at different degrees of detail using:
- USP Release Equipment for overall released amount
- MRI (magnetic resonance imaging) to reveal changes in the tablet structure during release
The structure and composition of the coating film can influence the release rate. The film can be studied in detail by
Binding of particles
The tablet strength is influenced by the interactions between the particles that build up the tablet.
Internal structure and location of material
The internal structure and the distribution of materials in the tablet can also influence both tablet strength and release rate.
Characterisation of liquid formulation
"My drug particle dispersion forms aggregates that settle. Why? Does this effect the release rate?"
This would be related to the properties of the particles, dispersing agents and continuous phase.
Dispersion stability is monitored over time using a Turbiscan instrument, which also gives information regarding the destabilisation mechanisms . Underlying factors are also particle size and ζ-potential.
The continuous phase
The continuous phase also influences the dispersion stability, e.g. through the rheology, or the composition.
Aggregate structure is important for deaggregation and release, and can be monitored by microscopy techniques of different degrees of sophistication.